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Pancreatic cancer is increasingly prevalent and characterized by a high mortality rate. Due to the limitations of current diagnostic methods, early-stage detection remains elusive, contributing to persistently low survival rates among affected individuals. Nanomaterials have garnered significant attention in cancer research for their potential diagnostic applications. Among these, MXenes – a novel family of two-dimensional nanomaterials composed of transition metal carbides, nitrides, and carbonitrides – are of particular interest due to their unique properties. These include high electrical conductivity, hydrophilicity, thermal stability, large interlayer spacing, tunable structure, and high surface area. These characteristics make MXenes highly effective for detecting trace amounts of various analytes. In addition, their tunable structure enables precise manipulation of their properties, allowing for optimized sensing responses. Montmorillonite nanoclay (MMT), a member of the smectite group of natural clay minerals, is known for its ability to promote bone development and influence cell behavior. When combined with MXenes, MMT forms promising nanocomposites for early pancreatic cancer detection through sensing applications. The Ti3C2 MXene-MMT nanocomposites exhibit potential as scaffold sensors capable of distinguishing cancerous from non-cancerous samples by observing the distinctive patterns in resistance changes. In addition, MXenes possess excellent selectivity, allowing for the reliable identification of targeted analytes from a complex mixture of chemical and biological analytes. Due to the advanced sensing capabilities of MXene-MMT composite scaffold sensors, they hold great promise for early cancer diagnosis and tissue regeneration, providing a novel therapeutic approach to improving patient outcomes.